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 Psychopharmacology Discussion Thread

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PostSubject: Psychopharmacology Discussion Thread   Wed Sep 21, 2011 7:59 pm

Hi Friends,

I will be posting important questions from Psychopharmacology section here .

Everyone is encouraged to participate by either posting questions/answering questions/posting doubts related to Psychopharmacology.



*****Discussion is the Most Effective Way of Learning *****


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PostSubject: Re: Psychopharmacology Discussion Thread   Thu Sep 22, 2011 7:02 pm

Clinical Vignettes: Drug Interactions with Antipsychotic Agents.

1. Patient on Quetiapine diagnosed with AIDS, started on Protease Inhibitor (HAART).
(a) What is the consequence of this interaction?
(b) What is the underlying mechanism responsible for this consequence?
(c) What will you do next?


2. Patient on Clozapine, Fluvoxamine added.
(a) What is the consequence of this interaction?
(b) What is the underlying mechanism responsible for this consequence?
(c) What will you do next?


3. Patient on Ziprasidone, started on Erythromycin
(a) What is the consequence of this interaction?
(b) What will you do next?
(c) What is the underlying mechanism responsible for this consequence?


4. Patient on Olanazapine starts smoking heavily
(a) What is the consequence of this interaction?
(b) What is the underlying mechanism responsible for this consequence?
(c) What will you do next?


5. Patient on Quetiapine, Carbamazepine added.
(a) What is the consequence of this interaction?
(b) What is the underlying mechanism responsible for this consequence?
(c) What will you do next?


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PostSubject: Re: Psychopharmacology Discussion Thread   Thu Sep 22, 2011 7:33 pm

6. Which of the following is NOT the treatment of choice for Typical antipsychotics induced severe hypotension:

(a) Metaraminol
(b) Norepinephrine
(c) Epinephrine
(d) All of the above
(e) None of the above

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PostSubject: Re: Psychopharmacology Discussion Thread   Thu Sep 22, 2011 7:52 pm

7. Which of the following statement is FALSE:

(a) Long term Thorazine use can cause reversible blue gray discoloration of skin areas exposed to sunlight
(b) Thorazine can cause benign pigmentation of eye
(c) Irreversible retinal pigmentation is associated with Thioridazine >1000mg/day
(d) Do not use emetics in suspected case of typical antipsychotic overdose
(e) Molindone is the most epileptogenic of all all typical antipsychotics
(f) All are correct
(g) All are wrong


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PostSubject: Re: Psychopharmacology Discussion Thread   Thu Sep 22, 2011 10:27 pm

8. Which of the following is FALSE regarding Antipsychotics:

(a) Cigarette smoking can reduce the plasma concentration of antipsychotic agents
(b) ACE inhibitors added to antipsychotics can result in postural intolerance
(c) Caffeinated beverages can possibly diminish the antipsychotic effects by forming a precipitate
(d) Disulfiram can decrease the antipsychotic concentration
(e) Antipsychotics can decrease the warfarin levels

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PostSubject: Re: Psychopharmacology Discussion Thread   Fri Sep 23, 2011 10:26 am

9. Which of the following is FALSE regarding "Transition of Antipsychotics":

(a) Transition from Clozapine to Olanzapine is safe in terms of cholinergc rebound.
(b) Transition from Olanzapine to Risperidone is safe in terms of cholinergc rebound.
(c) Transition from Clozapine to Ziprasidone is not safe in terms of cholinergc rebound
(d) All are correct
(e) All are wrong

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PostSubject: Re: Psychopharmacology Discussion Thread   Fri Sep 23, 2011 10:53 am

10. Which of the following Atypical Antipsychotic have LEAST RISK for EPS (Extra Pyramidal Symptoms)

(a) Olanzapine
(b) Risperidone
(c) Clozapine
(d) Quetiapine
(e) Aripiprazole

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PostSubject: Re: Psychopharmacology Discussion Thread   Fri Sep 23, 2011 9:36 pm

11. Based on ADA/APA recommendations, which of the following parameter is MOST FREQUENTLY monitored in patients on Atypical Antipsychotics.

(a) Personal/Family History
(b) Weight (BMI)
(c) Waist Circumference
(d) Blood Pressure
(e) Fasting Plasma Glucose
(f) Fasting Lipid Profile

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PostSubject: Re: Psychopharmacology Discussion Thread   Fri Sep 23, 2011 9:49 pm

12. Which of the following medication is least likely to cause Tardive Dyskinesia?

(a) Risperidone
(b) Ziprasidone
(c) Paliperidone
(d) Clozapine
(e) Quetiapine

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PostSubject: Re: Psychopharmacology Discussion Thread   Sat Sep 24, 2011 3:52 pm

13. Which of the following statement is FALSE regarding Sedative-Hypnotics?

(a) Zolpidem absorption can be delayed by 1 hr if taken immediately after heavy meal
(b) Doses above 2 mg of Flumazenil do not reliably produce additional effect in the treatment of benzodiazepine overdose
(c) Benzodiazepines can cause paradoxical increase in aggression in pt with preexisting brain damage
(d) Co-administration of Zolpidem and SSRIs can extend the duration of hallucinations in susceptible patients.
(e) Use of Tegretol (Carbamazepine) during benzodiazepine withdrawal permit better tolerated withdrawal than does gradual taper alone

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PostSubject: Re: Psychopharmacology Discussion Thread   Sat Sep 24, 2011 10:25 pm

14. Choose the correct Pregnancy Category Sequence of Following Medications:

(a) Zolpidem (Category B); Zaleplon (Category B); Ramelteon (Category B); Benzodiazepines (Category D)
(a) Zolpidem (Category A); Zaleplon (Category B); Ramelteon (Category C); Benzodiazepines (Category B)
(a) Zolpidem (Category B); Zaleplon (Category C); Ramelteon (Category C); Benzodiazepines (Category D)
(a) Zolpidem (Category B); Zaleplon (Category A); Ramelteon (Category B); Benzodiazepines (Category B)

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PostSubject: Re: Psychopharmacology Discussion Thread   Sat Sep 24, 2011 11:13 pm

Q15. Choose the correct statement regarding Sedatives-Anxiolytics-Hypnotics

(a) In PTSD pt with prominent insomnia and no comorbid depression: try trazadone first as hypnotic
(b) During the treatment of Social Anxiety: No need to start low and go slow
(c) Ramelteon can increase prolactin level in women by >30%
(d) All are correct
(e) All are wrong

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PostSubject: Re: Psychopharmacology Discussion Thread   Sun Sep 25, 2011 12:28 pm

Q16. Which of the following SSRI is least likely to complicate treatment due to drug interactions?

(a) Fluoxetine
(b) Fluvoxamine
(c) Paroxetine
(d) Citalopram



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PostSubject: Re: Psychopharmacology Discussion Thread   Mon Sep 26, 2011 6:42 pm

Q.17: Match the following drug interactions with responsible CYP450 enzyme:

(1) Fluvoxamine + Theophylline =Raises Theophyline
(2) Fluvoxamine + Cisapride = Raised QT Interval
(3) Nefazodone + Alprazolam = Raises Alprazolam
(4) TCAs + SSRIs =Raises TCAs
(5) Fluozetine + Triazolam = Raises Triazolam
(6) Carbamazepine Autoinduction
(7) Imipramine + Smoking= Decreases Imipramine level

(a) CYP450 1A2
(b) CYP450 2D6
(c) CYP450 3A4




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PostSubject: Re: Psychopharmacology Discussion Thread   Mon Sep 26, 2011 7:06 pm

Q18. Which of the following Statement is FALSE regarding Fluoxetine?

(a) Fluoxetine use during pregnancy is not associated with decrease in global IQ in children
(b) Only Fluoxetine is FDA approved for use as an antidepressant in children
(c) Most common adverse effect associated with long term use is sexual dysfunction
(d) Pt on Fluoxetine gain weight initially followed by weight loss.
(e) Fluoxetine can change the duration of menstrual period by more than 4 days

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